In Buddhism, the four basic elements (earth, water, fire, and wind) that make up the universe and the human body.

(Buddhism) A warrior attendant or guardian deity who protects the Buddha, typically depicted holding a thunderbolt weapon; also used as a shorthand for the 四大金刚 sì​dà​jīn​gāng.

The four largest companies in a specific industry, most commonly referring to the Big Four accounting firms or major commercial banks

(metaphor) A person who is physically strong, robust, or tall.