3 sentences

1. 双方在谈判中取得了实质性进展。

   shuāng​fāng zài tán​pàn zhōng qǔ​dé le shí​zhì​xìng jìn​zhǎn.

   The two sides have made substantive progress in the negotiations.

   Source: Dong Chinese Dictionary

2. 这些变化将对公司产生实质性的影响。

   zhè​xiē biàn​huà jiāng duì gōng​sī chǎn​shēng shí​zhì​xìng de yǐng​xiǎng.

   These changes will have a substantial impact on the company.

   Source: Dong Chinese Dictionary

3. 我们终于在双方合作方面迈出了实质性的一步。

   wǒ​men zhōng​yú zài shuāng​fāng hé​zuò fāng​miàn mài​chū le shí​zhì​xìng de yī bù.

   We have finally taken a substantive step in the cooperation between the two sides.

   Source: Dong Chinese Dictionary