for what reason; how come

inquiring about the state, quality, or condition of someone or something

in what way or manner; used to inquire about methods or conditions

what's to be done

in any case; no matter what

what; how; what's the matter; how about

not very, not particularly, or not much

not particularly good; unimpressive; of a poor or disappointing standard

(often used in early vernacular) but alas; however

how; in what way; what kind of (often used in early vernacular Chinese)

what is to be done; expressing panic or helplessness in the face of a dire situation

An expression of annoyance, frustration, or confusion regarding a person's behavior or a problematic state of affairs.

an idiom used to ask about the reason or nature of a situation, event, or incident, equivalent to 'what is going on' or 'what is the matter'.

the explanation for how a situation came about or what it is all about

Why is that?; How come?

what's up; what's going on; what happened (often used to express concern or ask about a perceived problem)

used to ask about the nature, condition, or cause of something, or to express inquiry regarding an action done to someone or something.

how can it be expressed in one word, "sorrow"?; how can words express such sadness? (originally the last line of the poem "Sheng Sheng Man" by Song poet Li Qingzhao)

how; what (happened); used to inquire about a state or manner

how can?

How do you mean? Used to ask the speaker to elaborate on or clarify the meaning of their previous statement.