Mississippi; referring to both the US state and the Mississippi River

Mississippi, a state in the southeastern United States.

Sicily, an island region of Italy; also known as Sicilia

an island located southwest of the Italian peninsula, which is the largest island in the Mediterranean Sea

The major river in the central United States, flowing from Lake Itasca to the Gulf of Mexico

Sisyphus (Greek mythological figure condemned to roll a boulder up a hill forever)