quite; rather; considerably; to a significant degree

(literary) how; what (used in questions or expressions of futility frequently with 何 hé)

(archaic) used to express doubt or a question similar to "is it possible" or "can it be"

(literary) but; however; unfortunately (expressing an unexpected turn or obstacle, often as 无奈 wú​nài or 怎奈 zěn​nài)