to be problematic from the start and worsen over time due to unfavorable conditions or mismanagement

那个新兴公司先天不足，后天失调，结果不到半年就倒闭了。

to be born with a weak constitution and suffer from ill health or poor development during one's life

这孩子先天不足，后天失调，需要加倍细心地照顾。