serious; grave; severe. Often used to describe a situation that has become problematic or out of control

careless; thick-skinned; insensitive. Used to describe someone who is oblivious or not detail-oriented, often in the phrase 神经大条 shén​jīng​dà​tiáo

(Taiwan colloquial) arrogant; overbearing; acting like a big shot.

(Taiwan colloquial) a large amount of money; a big sum.