Used to ask about the nature, condition, or way of doing something; often more formal than 怎么样 zěn​me​yàng

Used independently to emphasize that one's statement or behavior is correct, meaning "well?" or "what do you think?"

Used to express no matter how or in whatever way

Used to replace a specific behavior or situation that one does not want to state directly (e.g. "not all that good")

Used as a placeholder for an unspecified or indefinite state or action