how; what's it like; how about it; how are things; in what way

used in rhetorical questions or challenges to mean what can be done about it or what action can be taken against someone

used in the negative (often 不 bù 怎么样 zěn​me​yàng) to mean not very good, mediocre, or not up to much

used independently to emphasize that one's previous statement or prediction was correct; See? or What did I tell you?